Assassin's Creed: Brotherhood

From Before I Play
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  • In addition to looting treasure chests, remember to loot corpses. Looting soldiers can give you a good early income as well as save you money on buying medicine, poison and other expenses.
  • You will find "Trade Items" while looting corpses and treasure chests. The shops nearest to Ezio's home base have "Shop Quests", which give you unique equipment in exchange for specific items.
  • Items that are required for Shop Quests and shouldn't be sold until a related quest is completed: Terracotta Pot, Totem, Buddhist Prayer Beads, Shrunken Head, Elephant Ivory, Indian Diamond, Vlad The Impaler Coins, Pomander, Ambergris, Papaver Silvaticum, Silk, Cardinal's Purple Dye, Tomatoes, Nutmeg, Aconite.
  • Items that are safe to sell: Alum, Claddagh Ring, Coffee Beans, Copper Ore, Gold Ingot, Green Jasper, Incense, Jar Of Leeches, Jeweled Headdress, Piper Nigrum, Quicksilver, Rabbit's Foot, Red Jasper, Saffron, Sapphire, Silver Ore, Tartar Emetic, Velvet, Venetian Poison Ring, Wool.
  • Renovating Rome can be very lucrative. Banks, blacksmiths and stables provide very good return on investment and should be bought early on to maximize income.
  • In contrast, Landmarks provide nearly no income at a very high cost.
  • Renovating Aqueducts opens up a side mission as well as giving you a good return on investment.
  • Unlike ACII, buying paintings and equipment won't increase your income.
  • Buy the crossbow in the blacksmith shop as soon as possible. Most mid-game onwards enemies cannot be silently killed from range with throwing knives.
  • Complete all of the Leonardo missions as soon as possible for a unique equipment upgrade.
  • Maps showing Feather and Flag locations become available for purchase in the post-game.
  • After the Sequence 8 mission in the Colosseum, make sure you're set with your equipment etc. as the next mission will kick off the endgame, which locks you into your current loadout (until you beat it).
  • Don't drive yourself crazy trying to get Full Synch on every mission. Full Synch opens up a few optional missions and 75% overall Synch will unlock them all. Getting 100% on a given Sequence unlocks a cheat code, but those can only be used when replaying missions.